Articles and Research

The strategy of medical therapy of Crohn's disease

Crohn's disease is characterized by a variety of clinical manifestations, and complications associated with the fact that the disease process is transmural in nature and may be localized in any part of the digestive tract - from the mouth to the anus. This diversity makes quite innovative approaches to therapy.

Ulcerative colitis: pharmaceutical aspects

Ulcerative colitis (UC) - a chronic relapsing disease of the colon of unknown etiology, characterized by hemorrhagic-purulent inflammation of the colon with the development of local and systemic complications. Accurate data on the prevalence of UC is difficult to obtain, as the mild cases of UC, especially in the initial period of the disease, often go unreported. Patients in these cases tend to occur in specialized outpatient facilities and incalculable.

Local therapy forms the distal ulcerative colitis

Distal ulcerative colitis - a concept that includes 3 main forms of the disease, proctitis - inflammation extending up to 20 cm from the anal verge, proctosigmoiditis (20 to 40 cm) and left-sided colitis (40-80 cm). They add up to 60-70% of all cases of ulcerative colitis, are important features of the pathogenesis, clinical manifestations and treatment, distinguishing them from total defeat of the colon. These differences are due to unequal functional activity of the right and left-half colon motility characteristics, absorption and metabolism of the intestinal wall.

Current approaches to the treatment of patients with ulcerative colitis

Treatment of patients with ulcerative colitis - an extremely complex problem, the realization of which should arise from the degree of activity of the disease, the prevalence and localization process, the presence of certain complications. You must also take into account the individual characteristics of the patient's age, sex, comorbidity, possibility of drug intolerance.Proper assessment of the above factors that determine a particular medication regimen, increases the likelihood of successful solutions Gastroenterologist, its tasks:

Optimization methods colonoscopy patients with irritable bowel syndrome

Irritable bowel syndrome or irritable bowel syndrome (IBS) is a common disease and is most common in young persons (under 45 years). [1] In patients with IBS in the presence of non-ulcer symptom of colitis revealed only disturbances in motor and secretory function of the colon without signs of inflammation of the mucous membranes and other organic pathology. The etiology of this syndrome is not completely installed. IBS often refers to psychosomatic diseases [2].

Intestinal dysbiosis

In the human intestine is 500 species of microbes, the total amount of which reaches 1014 which is much higher than the total number of cellular composition of the human body. Normal microbial flora is one of the barriers to bacteria entering the intestines [Y]. It stimulates the immune defense, increases the secretion of IgA in the lumen of the intestine. Escherichia coli, enterococci, bifidobacteria and Lactobacillus acidophilus have strong antagonistic properties and are able to suppress the growth of pathogenic microorganisms.

Irritable bowel syndrome associated with dysbiosis

Prevalence and causes

Irritable bowel syndrome: diagnosis and treatment

Diagnostically difficult are clinical situations when severe symptoms of the disease can not be explained in the results of laboratory, instrumental and morphological studies. Irritable bowel syndrome (IBS) is a shining example of this situation.

Crohn's disease: characteristics of pathogenesis, clinic and treatment

Terminal ileitis was nosologically contoured shape only after work B.Crohn, in 1932, described in detail the clinical picture of the 14 cases. Further observations showed that the inflammatory process similar to that described, not only affects the small intestine, but can be more or less frequently extend to all parts of the digestive tract, and going blind gut (V.Crown, 1949), stomach, and duodenum (H. Fahimi et al., 1963), esophagus (N.Dyer et al., 1969).

Pseudomembranous colitis and "intestinal sepsis" - a consequence of dysbiosis caused by antibiotics

Adverse effects of unreasonable or irrational use of antibiotics have long been known. Among them are usually specified the development of antibiotic-resistant strains of pathogens, candidiasis, dysbiosis. Recently, as the development of new antibacterial broad-spectrum drugs, acquired special significance. In this regard, more alarming lack of awareness of the population and (most dangerously) many practitioners of the high risk of unjustified and unsystematic use of powerful modern antibacterial agents.