Hot chilli may be the key to lose weight, say Adelaide University researchers

University of Adelaide researchers have discovered a high-fat diet may impair important receptors located in the stomach that signal fullness. Published today in the journal PLOS ONE, researchers from the University's Centre for Nutrition and Gastrointestinal Diseases (based at the South Australian Health and Medical Research Institute) investigated the association between hot chilli pepper receptors (TRPV1) in the stomach and the feeling of fullness, in laboratory studies.

Opioids produced by yeast; revealing the potential for cheaper pain relief

Researchers at Stanford University have genetically engineered yeast so it produces hydrocodone, a semi-synthetic opioid analgesic used in the United States for relief of moderate to severe pain.

FDA accepts Allergan's resubmission of BOTOX sBLA for treatment of adults with upper limb spasticity

Allergan plc (NYSE: AGN), a leading global pharmaceutical company today announced that the U.S. Food and Drug Administration (FDA) has accepted the company's resubmission of its Supplemental Biologics License Application (sBLA) for BOTOX® (onabotulinumtoxinA) for the treatment of adults with lower limb (involving ankle and toe muscles) spasticity in adults. A six-month review period has been assigned for the sBLA. The Prescription Drug User Fee Act (PDUFA) date is expected to be in the first quarter of 2016.

Failure To Rescue After Complications Defines Lung Cancer Resection Survival

The variation in mortality rates among patients undergoing lung cancer resection in US hospitals has been attributed by a cohort study to differences in failure-to-rescue (FTR) rates after the development of complications. “Thus, a better understanding of the cause of failure to rescue may be crucial for improving mortality rates following lung cancer resection”, the study authors suggest in JAMA Surgery.

Stroke more likely if you work long hours, major study finds

People who work long hours are at a greater risk of stroke and coronary heart disease than people who work a standard week, according to the largest study of the issue to date, published in The Lancet. The research showed that working for 55 hours or more a week increased the risk of stroke by 33% and the risk of coronary heart disease by 13% compared with working a standard 35 to 40 hour week. The findings suggest that individuals who work long hours need to pay more attention to managing any vascular risk factors.

Eating on the move may trigger weight gain in dieters

The study, conducted by researchers from the University of Surrey in the UK, found that eating while walking could make dieters overeat later on in the day, triggering more overeating than other forms of distraction such as watching TV or chatting with a friend.

New metformin may help more patients with type 2 diabetes

The revelation, published in the journal Diabetes Care, means that a delayed-release form of metformin that the researchers tested could suit the 40% of type 2 diabetes patients who cannot use the current formulation. Metformin (short for metformin hydrochloride, also known as Glucophage and other brand names) has been used in the treatment of type 2 diabetes for nearly 60 years. Despite the drug's veteran status, scientists are not exactly sure how and where in the body most of its glucose-lowering effect takes place.

'Stress hormone' levels in saliva could pinpoint seniors with cognitive decline

Published in the journal Neurology, the study reveals older individuals with high levels of the "stress hormone" cortisol in their saliva had smaller brain volumes, which was associated with poorer performance on tests of memory and thinking.

Scientists discover 'obesity master switch' for burning or storing fat

The discovery - published in The New England Journal of Medicine - may lead to new approaches to prevent and even cure obesity, says the team, from Massachusetts Institute of Technology (MIT) in Cambridge, and Harvard Medical School in Boston, MA. Obesity is one of today's biggest challenges to global health. It affects over 500 million people worldwide and contributes to type 2 diabetes, cancer, and cardiovascular disorders - all diseases that can lead to early death.

Longer working hours linked to greater stroke risk

The research also reveals that those who work long hours may also be at higher risk of developing coronary heart disease. The study, published in The Lancet, is the largest of its kind to investigate the link between working hours and cardiovascular health. According to the Centers for Disease Control and Prevention (CDC), coronary heart disease and stroke are currently ranked first and fifth, respectively, in the top 10 causes of death in the US.